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Spironolactone In The Treatment Of Acne
In his article on acne published recently in the New England Journal of Medicine James (1) mentions that androgen antagonist spironolacton is often useful in women with hyperandrogenism. However, it would be important to point out, that the effectiveness of this treatment cannot be determined due to the small sample populations involved in the trials, as has been shown in recent metaanalysis. (2) It should be also emphasized that although the long-term use of spironolactone in the treatment of acne in women appears to be safe, its side-effects seem to be high. (3) On the other hand, it is worth mentioning that spironolactone in addition to its antiandrogenic effects might also have antiinflammatory potential. (4) This emphasizes the need for further properly designed trials with relevant outcomes to provide robust estimates of the size and mechanism of any treatment effects. Because of its long half-life spironolactone should be given once daily and not in divided doses as recommended by James. This might increase the compliance which is important in prolonged therapy to achieve maximal benefits. (5)
1. James WD. Clinical practice. Acne. N Engl J Med 2005;352:1463-72.
2. Farquhar C, Lee O, Toomath R, Jepson R. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Cochrane Database Syst Rev 2003;(4):CD000194.
3. Shaw JC, White LE. Long-term safety of spironolactone in acne: results of an 8-year followup study. J Cutan Med Surg 2002;6:541-5.
4. Hansen PR, Rieneck K, Bendtzen K. Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells. Immunol Lett 2004;91:87-91.
5. McEvoy B, Nydegger R, Williams G. Factors related to patient compliance in the treatment of acne vulgaris. Int J Dermatol 2003;42:274-80.
About the author:
Dr. Michal R. Pijak is a consultant in rheumatology, allergy and clinical immunology at the University Hospital in Bratislava, Slovakia.
Natural Acne Treatment
Natural acne treatments are desirable because they have few side effects, are inexpensive, and are effective for many. There are many natural acne treatments available for purchase. These contain various plant extracts that work to dry up the pimple and sooth the skin
Most of these products contain vitamin E, grapeseed oil, calendula, aloe vera, witch hazel or essential oils. For example, tea tree oil applied to acne has been found to be effective for hundreds of years. An herbal blend that can help with acne consists of equal parts of the herbal extracts of sarsaparilla, yellow dock, burdock, and cleavers. Take half a teaspoon of this blend three times daily.
Maintain a healthy k...
Eczema And Acne Herbs For A Powerful Footbath
In 1979, Maurice Messe’gue’, the famous French herbalist, who practiced herbal footbaths for all kinds of ailments, wrote a book called “Health Secrets of Plants and Herbs.” In this book he outlined his footbath treatment for Eczema.
I have listed his herbal recommendations and have added a few more that are effective in reducing eczema symptoms. I have listed 11 herbs that you can buy in small quantities, ½ oz, to mix together, produce a tea, and use in a footbath.
As mentioned in my other article on footbaths, create a tea, with herbs and let them sit for 20-30 minutes. Then strain and add them to a footbath. Use the footbath in the morning and evening for 10 – 14 ...
The Sad Tales Of Adult Acne
The tales of adult acne has ever been a silent one, only told as whispers and an unfortunate few suffered from it, some may even refuse to show themselves to the world. The manifestation of adult acne has been recognized during the Eighties, when the yuppie generation has standardized of what is to become the hip urban lifestyle free of adult acne and any other lesions.
Though adult acne is one aesthetic issue that is quite preval...
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